Abstract
Background. Primary tumoral calcinosis is an orphan disease. There are few data in the literature on the incidence of this disease, as well as clinical recommendations for treatment.
 Clinical case. This report presents the case of an 11.5-year-old boy with primary tumoral calcinosis and equinus deformity of the foot. The patient had multiple foci of the subcutaneal calcification, cannot walk, experienced fatigue, and had high fever and equinus deformity of the left foot. Immunological and genetic studies were performed, but any specific mutations were not found. After the diagnosis was verified and interleukin-1 inhibitor therapy was prescribed, there was a significant positive trend observed in the patient: a significant improvement in the patients general condition, a decrease in the number of calcinates, and a reduction in inflammation. Calcification of the Achilles tendon and gastrocnemius muscle was the cause of the deformity of the left foot.
 Discussion. Significant improvement was achieved during treatment: the boy started walking, fatigue was decreased, no new calcificates were formed, and inflammation was under the control. Using an inhibitor of interleukin-1 as a permanent therapy of primary tumoral calcification allowed performsurgical treatment without complications from an operation site, as well as a relapse of deformity.
 Conclusion. The clinical case presented here demonstrated the application of an interdisciplinary approach to the treatment of an extremely rare disease.
Highlights
Клинические случаиПЕРВИЧНЫЙ ОПУХОЛЕВЫЙ (ТУМОРАЛЬНЫЙ) КАЛЬЦИНОЗ — РЕДКОЕ ЗАБОЛЕВАНИЕ В ПРАКТИКЕ РЕВМАТОЛОГА И ОРТОПЕДА: ОПЫТ ПРИМЕНЕНИЯ ИНГИБИТОРА ИНТЕРЛЕЙКИНА-1 В СОЧЕТАНИИ С ХИРУРГИЧЕСКОЙ КОРРЕКЦИЕЙ
Primary tumoral calcinosis is an orphan disease
This report presents the case of an 11.5-year-old boy with primary tumoral calcinosis and equinus deformity of the foot
Summary
ПЕРВИЧНЫЙ ОПУХОЛЕВЫЙ (ТУМОРАЛЬНЫЙ) КАЛЬЦИНОЗ — РЕДКОЕ ЗАБОЛЕВАНИЕ В ПРАКТИКЕ РЕВМАТОЛОГА И ОРТОПЕДА: ОПЫТ ПРИМЕНЕНИЯ ИНГИБИТОРА ИНТЕРЛЕЙКИНА-1 В СОЧЕТАНИИ С ХИРУРГИЧЕСКОЙ КОРРЕКЦИЕЙ. Представлен клинический случай лечения пациента 11,5 года с первичным опухолевым кальцинозом и эквинусной деформацией левой стопы. Благодаря применению ингибитора интерлейкина-1β в качестве постоянной терапии первичного опухолевого кальциноза удалось выполнить хирургическое лечение без осложнений со стороны послеоперационной раны, а также предотвратить рецидив деформации. Представленный клинический случай демонстрирует применение междисциплинарного подхода к лечению крайне редкого заболевания. При отсутствии клинических рекомендаций по лечению и диагностике первичного опухолевого кальциноза верификация правильного диагноза и применение комплексного лечения позволили добиться значительного улучшения качества жизни пациента. Для цитирования: Петухова В.В., Идрисова Р.В., Снегирева Л.С., и др. Первичный опухолевый (туморальный) кальциноз — редкое заболевание в практике ревматолога и ортопеда: опыт применения ингибитора интерлейкина-1 в сочетании с хирургической коррекцией // Ортопедия, травматология и восстановительная хирургия детского возраста.
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