Abstract
BackgroundPrimary squamous cell carcinoma of the endometrium is an extremely rare tumor with poorly understood pathogenesis.Case presentationWe report a case of a 28-year-old Togolese woman who had consulted for vaginal bleeding and pelvic pain. Ultrasound showed thickening of the lining of the endometrium, and biopsy curettage was done. Anatomopathological examination was noteworthy for a proliferation of squamous cells often connected by union bridges arranged in tumor lobules with dyskeratotic maturation. Immunohistochemistry showed epithelial membrane antigen positivity, anti-pancytokeratin 1 markers of tumor cells positivity, chromogranin A negativity, actin negativity, S100 negativity, estrogen receptor negativity, and progesterone receptor negativity. In situ hybridization had objectified human papillomavirus genotypes 16/18. The diagnosis of primary squamous cell carcinoma of the endometrium associated with human papilloma virus was retained. A hysterectomy was performed, and the tumor was classified pT1N0M0.ConclusionThe pathogenesis of this endometrial cancer is complex, and its association with human papillomavirus does not explain its genesis.
Highlights
BackgroundPrimary squamous cell carcinoma (PSCC) of the endometrium is an extremely rare tumor [1]
Primary squamous cell carcinoma of the endometrium is an extremely rare tumor with poorly understood pathogenesis.Case presentation: We report a case of a 28-year-old Togolese woman who had consulted for vaginal bleeding and pelvic pain
Given the extreme rarity of Primary squamous cell carcinoma (PSCC) of the endometrium and the fact that all the previously reported cases have been in menopausal women, we report a case of exceptional localization of PSCC of the endometrium associated with Human papillomavirus (HPV) in a young Togolese woman
Summary
Primary squamous cell carcinoma (PSCC) of the endometrium is an extremely rare tumor [1]. Darré et al Journal of Medical Case Reports (2019) 13:167 with a 1-week history of bleeding and pelvic pain She reported her age at first menstrual period as years old and her age at first sexual intercourse as years old. The patient had no medical, obstetric, social, environmental, or special family history She had never received an intervention, and she had a good psychosocial state. There was palpable lymphadenopathy in the region of the inguinal lymph nodes Her gynecological speculum examination showed a macroscopically healthy uterine cervix. Abdominal ultrasound showed regular thickening of the endometrium, measuring 19 mm thick, and no substantial masses (Fig. 1) After 3 and 6 months of follow-up, the patient was well, without recurrence
Sign-in/Register to view highlights & summary Sign-in/Register to access full text options 
Free) 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a call
