Abstract
BackgroundSolitary plasmacytoma of the liver is a very rare and aggressive form of plasma cell dyscrasia. To the best of our knowledge, very few cases have been reported without systemic disease. We reported a rare case of hepatic solitary plasmacytoma that successfully responded to fractionated stereotactic radiotherapy.Case presentationA 64-year-old white French man had monoclonal gammopathy of the immune globulin G lambda type; he developed a cholestasis and cytolysis with the discovery of a subscapular nodule. A biopsy showed plasma cells and, for several reasons, the decision was made to use the fractionated stereotactic radiotherapy strategy. After 20 months, he is asymptomatic and the immune globulin G component has completely disappeared.ConclusionWe suggest considering Cyberknife® radiosurgery as an option for the treatment of hepatic solitary plasmacytoma.
Highlights
BackgroundSolitary plasmacytoma (SP) is a rare form of plasma cell dyscrasia with a single bone (SBP) or extramedullary location (EMP)
Solitary plasmacytoma of the liver is a very rare and aggressive form of plasma cell dyscrasia
The presence of plasma cells in the liver or spleen is known to be associated with a more aggressive form of multiple myeloma [3] that usually requires a heavy treatment with chemotherapy or consolidation therapy with autologous hematopoietic stem cell transplantation
Summary
Solitary plasmacytoma (SP) is a rare form of plasma cell dyscrasia with a single bone (SBP) or extramedullary location (EMP). Fractionated stereotactic radiotherapy has been used for approximately two decades to deliver ablative high-dose irradiations to small target volumes and low-dose irradiations to adjacent normal tissue It plays an increasingly important role in the therapeutic arsenal of primary and secondary liver tumors but, to the best of our knowledge, its use has never been described in the treatment of hepatic plasmacytoma. Case presentation A 64-year-old white French man had stable monoclonal gammopathy of the immune globulin G (IgG) lambda type (IgG = 1 g/L) with normal bone X-rays. He had no other significant comorbidities, except for diabetes and hypertension.
Sign-in/Register to view highlights & summary Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
