Abstract
Angiomyolipoma is an extremely rare neoplasm in animals. It belongs to a group of perivascular epithelioid cell tumours (so-called PEComas). This study reports a case of primary soft tissue angiomyolipoma in a dog with some unusual clinical features. A 4-year old female Labrador dog with a rapidly growing pelvic tumour measuring 30 × 20 cm with a short history of 12 weeks was presented. The tumour was well-circumscribed and pushed into the right vaginal wall and into the perineum. The tumour was completely surgically excised. An extensive histological examination was performed, including immunohistochemical analysis. Histology revealed a mesenchymal neoplasm consisting of three tissue components – mature adipose tissue (which dominated), vessels, and smooth muscle (spindle) cells. The lesion showed positive immunohistochemical staining with smooth muscle actin and desmin in mature-appearing smooth muscle cells and S-100 protein positivity in adipocytes. The diagnosis of angiomyolipoma must be considered in different types of benign and malignant tumours of various lineages. The diagnostic approach to soft tissue tumours, including angiomyolipoma, requires optimal processing and sectioning of resected specimens. This paper is believed to be the first case of primary soft tissue angiomyolipoma reported in the veterinary literature.
Highlights
Angiomyolipoma (AML) belongs to a group of perivascular epithelioid cell tumours referred to as PEComas
This study reports a case of primary soft tissue angiomyolipoma in a dog with some unusual clinical features
Histology revealed a mesenchymal neoplasm consisting of three tissue components – mature adipose tissue, vessels, and smooth muscle cells
Summary
A 4-year-old intact female dog with a rapidly growing pelvic mass was presented. All clinical examinations, including ultrasound and surgery, were performed at the Department of Surgery and Orthopaedics of the Faculty of Veterinary Medicine, University of Veterinary Sciences Brno. A clinical examination was performed with the following results. An abdominal and pelvic ultrasound revealed a large 30 × 20 cm tumour located on the right lateral wall of the vagina extending into the perineum. The following day, surgery was performed and the tumour was completely removed. Histological examination revealed mesenchymal neoplasm composed of an admixture of adipose tissue, vessels and smooth muscle (spindle) cells. Minor areas consisting of bundles of smooth muscle cells, with focally immature appearance, and thickwalled, medium to large sized vessels were focally present (Plate VII, Fig. 1A-D). The following antibodies were employed: S100 protein (polyclonal, ready to use [RTU], Roche, Basel, Switzerland), HMB-45 (monoclonal, clone HMB-45, RTU, Roche), Melan-A (monoclonal, clone A103, RTU, Roche), smooth muscle actin (SMA) (monoclonal, clone 1a4, RTU, Roche) and desmin (monoclonal, clone DE-R-11, RTU, Roche). Publication Boisclair and Doré 2001 Jakab et al 2013 Wang et al 2001 Present case
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