Abstract
Primary pure small cell carcinoma of the urinary bladder is an extremely rare and highly aggressive tumor with an average five-year survival rate of less than 10% as cited by multiple case reports. It accounts for about 0.5-1% of all bladder tumors. We present the case of an 87-years-old man; smoker hospitalized in the Department of Urology, from the Institute of Medicine, Kathmandu for intermittent painless hematuria. Ultrasonography showed a sessile tumoral growth. Transurethral resection of the tumor mass was performed and tissue fragments were sent to the pathologic lab to establish the histologic type, the degree of differentiation and invasion. Fragments of the tumor were fixed in 10% formaldehyde, paraffin embedded and processed as standard technique; the sections were stained with H and E and immunohistochemically with NSE and Cytokeratin. A diagnosis of small cell carcinoma was established. Because of aggressive behavior and distinct treatment, the pathologist should watch out for the presence of small cell carcinoma component.
Highlights
Primary small cell carcinoma of the bladder is a rare entity accounting for less than 1% of all bladder tumors.[1]
We hereby report a case of primary small cell carcinoma of urinary bladder who presented with intermittent painless hematuria
Fragments of the tumor were ixed in 10% formaldehyde, parafin embedded and processed as standard technique; the sections were stained with H and E and immunohistochemically with neuron speciic enolase (NSE) and Cytokeratin
Summary
Primary small cell carcinoma of the bladder is a rare entity accounting for less than 1% of all bladder tumors.[1]. We hereby report a case of primary small cell carcinoma of urinary bladder who presented with intermittent painless hematuria. Fragments of the tumor were ixed in 10% formaldehyde, parafin embedded and Figure 1: Tumor cells in sheets and nests invading the lamina propria (HE stain; X100). Hematoxylin and eosin slides were examined under light microscopy which revealedtumor cells in sheets and nests invading the lamina propria (ig.[1]). These tumor cells showed mild to moderate pleomorphism with scant amount of cytoplasm. Based on these features a diagnosis of Small cell carcinoma of the urinary bladder was given. X-ray and CT scan of the lung was normal
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