Abstract
Primary sclerosing cholangitis (PSC) is a chronic cholestatic disease characterized by fibrosis leading to progressive stricturing of the biliary system. It was first described in 1874, but more than a century later, fewer than 100 cases had been reported. However, in the last 25 years the development of endoscopic and radiologic techniques allowed the diagnosis of PSC to be made without resort to surgery or postmortem examinations. This led to the realization that PSC was much more common than previously thought. Since 1980, more than 1500 articles on PSC have been published.
Published Version
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