Primary Sclerosing Cholangitis and Brush Cytology Sampling

Abstract

Primary sclerosing cholangitis (PSC) is associated with the development of cholangiocarcinoma in up to 10% of patients. Efforts should be made to detect early neoplastic changes that can be treated radically by liver transplantation. However, at cholangiography this condition is most often indistinguishable from a benign dominant stricture. Although the sensitivity of brush cytology for dominant strictures in PSC is rather poor (50–70%), in many cases it represents the only suitable diagnostic tool to confirm suspected malignancy. The author demonstrates a case with PSC and brush cytology sampling from dominant stenoses. This article is part of an expert video encyclopedia.