Abstract
Primary Renal Sarcoma is rare tumor comprising only 1% of all renal tumours. Synovial sarcomas are generally deep-seated tumors arising in the proximity of large joints of adolescents and young adults and account for 5–10% of all soft tissue tumours. Primary synovial sarcoma of kidney is rare and has poor prognosis. It can only be diagnosed by immunohistochemistry. It should be considered as a differential in sarcomatoid and spindle cell tumours. We present a case of 33-year-old female, who underwent left sided radical nephrectomy for renal tumour. Histopathology and genetic analysis diagnosed it to be primary renal synovial sarcoma. Patient underwent radiation therapy and 2 years follow up is uneventful. A brief case report with review of literature is presented.
Highlights
Primary renal synovial sarcoma (PRSS) was initially described by Faria et al in 2000 which was previously included in embryonal sarcomas of the kidney.[1,2,3]
We present a case of PRSS which was diagnosed by genetic analysis
PRSS is a rare tumour of kidneys which can be diagnosed on histopatholgy combined with immunohistochemistry and genetic analysis
Summary
Primary renal synovial sarcoma (PRSS) was initially described by Faria et al in 2000 which was previously included in embryonal sarcomas of the kidney.[1,2,3] Detection of characteristic cytogenetic abnormality t(X, 18) within this group of tumors led to the recognition of a renal synovial sarcoma. Computed tomography (CT) scan showed a mass of approximately 20¥12¥11.5 cm arising from the lower pole of the left kidney. It was extending from left renal fossa to left iliac region with areas of hemorrhages and necrosis in it (Figures 1 and 2). Genetic analysis confirmed presence of SYT-SSX2 (X, 18) translocation Her 2 years follow up has shown her to be disease free
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