Abstract
Primary renal lymphoma (PRL) is a rare lymphoid malignancy with only a few cases reported in the literature. We performed a population-based study of PRL to determine its incidence, clinical characteristics and factors associated with survival using the Surveillance, Epidemiology, and End Results (SEER) database. We identified 723 patients with PRL. The most common histological subtype of PRL was diffuse large B-cell lymphoma (56.3%). The incidence and mortality rate of PRL was 0.053/100,000 person-years and 0.036/100,000 person-years, respectively. The incidence rate of PRL was increasing significantly with an annual percentage change (APC) of 3.45% (p < 0.001). The 1-year and 5-year relative survival (RS) rates of patients with PRL were 78% and 64%. The RS of patients diagnosed between 2000 to 2013 was better than that of patients diagnosed between 1980–1999. A multivariate Cox hazards regression analysis revealed that older age, male gender, diagnosis before 2000, advanced stage, not receiving surgical treatment, and DLBCL or T/NK cell lymphoma type were independent predictors of unfavorable survival.
Highlights
Primary renal lymphoma (PRL) is a rare disease that comprises less than 1% of extranodal lymphomas[1]
Most patients had a unilateral involvement of the left side (48.3%) or right side (39.1%), while 57 patients (7.9%) had bilateral presentation (Table 1)
423 patients (58.5%) died during the study period. 59.8% of the deaths resulted from PRL
Summary
The SEER database is a program of the National Cancer Institute, representing nearly 30% of the US population from 18 registries currently This population-based program collects information on patient demographics, morphology and site of primary tumor, follow-up and outcomes. We used International Classification of Diseases for Oncology, 3rd edition (ICD-O-3) histologic codes 9590–9595, 9650–9699 and 9702–9729 for lymphoma and primary site code C64.9 for the kidney to identify all patients with PRL diagnosed between 1980 and 2013 (Fig. 1). To estimate long-term incidence, we obtained a cohort of patients with PRL from the SEER-9 database from 1980 to 201311. The following patient-specific information was extracted: age at diagnosis, gender, race, year of diagnosis, marital status, laterality, morphological subtype, cancer stage, therapy type, the length of survival and the cause of death as recorded in the database. This article does not contain any studies with human participants or animals
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