Abstract
The involvement of the ovary by malignant lymphoma is a well-known late manifestation of disseminated nodal disease. Primary ovarian lymphoma is rare. We herein describe a case of primary ovarian diffuse large B-cell lymphoma involving unilateral ovary in a 38-year-old woman which was detected incidentally. Preoperative ultrasonic imaging showed a 46∗42 mm heterogeneous cystic mass. Laparotomy revealed that left adnexal mass and left salpingo-oophorectomy was performed. The current diagnosis was determined after immunostaining. The patient was treated with R-CHOP regimen after the operation. She remains cancer-free 24 months after chemotherapy.
Highlights
Lymphomas presenting as ovarian tumors are uncommon and may occur as de novo or secondary as a part of systemic disease [1]
Primary ovarian non-Hodgkin’s lymphoma (NHL) is an extremely rare disease as other primary lymphomas of the genital tract, accounting for 0.5% of all NHLs and 1.5% of all malignant ovarian neoplasms [2]
Fox et al have suggested three criteria for the diagnosis of primary ovarian lymphoma: (1) tumor has confined to the ovary regional lymph nodes or adjunctive organs at the time of the diagnosis, (2) bone marrow and peripheral blood have not contained any abnormal cells, and (3) if extraovarian disease appear later, there must be a few months between the time of ovarian and extra-ovarian lesions [3]
Summary
Lymphomas presenting as ovarian tumors are uncommon and may occur as de novo or secondary as a part of systemic disease [1]. Fox et al have suggested three criteria for the diagnosis of primary ovarian lymphoma: (1) tumor has confined to the ovary regional lymph nodes or adjunctive organs at the time of the diagnosis, (2) bone marrow and peripheral blood have not contained any abnormal cells, and (3) if extraovarian disease appear later, there must be a few months between the time of ovarian and extra-ovarian lesions [3]. The most common type of lymphoma involving the ovary is diffuse large B-cell lymphoma [4] In this case we present a case of primary ovarian large B-cell lymphoma, which was diagnosed using immunohistochemistry. Ultrason examination showed a 46∗42 mm heterogeneous cystic mass surrounded by thick wall and containing intense fluid in the left ovary whereas the right ovary was normal.
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