Abstract
An uncommon but significant cause of ovarian hormone deficit and infertility in women is Primary Ovarian Insufficiency (POI). In addition to leading to infertility, POI is linked to many health problems, including troublesome menopausal symptoms, lower bone density and an increased risk of fractures, early cardiovascular disease development, a potential early reduction in cognition, and dry eye syndrome. It is essential to provide women with POI with the proper Hormone Replacement Treatment (HRT) to replace premenopausal levels of ovarian sex steroids and reduce the health concerns that come with them. Using HRT formulations that nearly resemble natural ovarian hormone production is advised in this evaluation. HRT should be continued until the typical age of natural menopause, 50 years old. Keywords: Primary Ovarian Insufficiency, Hormone Replacement Treatment, Menopausal Symptoms
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