PRIMARY ORAL SOFT TISSUE ANGIOSARCOMA OF ORAL CAVITY IN A YOUNG PATIENT: CASE REPORT

Abstract

Angiosarcoma is a rare and aggressive malignant tumor that has a poor prognosis and occurs predominantly in elderly patients, usually in the trunk and limb region. It represents less than 1% of all malignant tumors occurring in the oral cavity. A 31-year-old man presented an extensive sessile nodule, which was asymptomatic and erythematous in the alveolar ridge extending to hard palate. Histologically, the tumor consisted of spindle and polygonal cells with hyperchromatic nuclei and prominent nucleoli. These cells are sometimes arranged in a stent-shaped pattern or form numerous vascular structures of varying calibers. The tumor had invasion in the surrounding tissue, and lymphovascular permeation was noted. Grocott staining was negative. Immunohistochemically, tumor cells were positive for CD34 in vessels and scattered cells, with Friend leukemia integration site 1 in spindle cells and Ki-67 labeling greater than 15%, concluding the pathologic diagnosis of angiosarcoma. Metastatic lesions are found in upper limbs and thorax. Radical surgery is now planned associated with chemotherapy.