Abstract
A 46-year-old man consulted a general dentist with the chief complaint of pain in the mouth, of 2 months' duration. Clinically, numerous irregular nodules were observed, distributed in the edentulous alveolar maxillary and mandibular ridges. Incisional biopsy was performed, and microscopic evaluation revealed an intense chronic inflammatory infiltrate in the submucosa with a granulomatous pattern, including giant multinucleated cells and macrophages containing a fungus. Special stains, the Grocott-Gomori methenamine silver and periodic acid–Schiff were reactive for Histoplasma capsulatum. Based on the clinical presentation and microscopic features, the final diagnosis was histoplasmosis. The patient was referred to an infectious disease specialist for treatment. This case report reinforces the importance of microscopic analysis to investigate primary oral manifestations of fungal diseases to establish an accurate diagnosis and treatment for the patient.
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