Primary Non Hodgkins Lymphoma Of Bilateral Breasts: A Rare Entity

Gireesha Rawal,Amit Kumar Yadav,Ashish Kumar Mandal,Sufian Zaheer

doi:10.21276/apalm.1335

Abstract

Extranodal Non-Hodgkin's Lymphoma (NHL) of the breast is a rare entity, repr esenting 0.04-1.1% of malignant tumours of the breast. Most breast lymphomas are the non-Hodgkin’s B cell type, with DLBCL being the most common. We present the case of a 32 years old female who presented with bilateral hard breast lumps, which were clinicoradiologically thought to be carcinomas. But on histopathology and immunohistochemistry, it was finally diagnosed as alymphoma. Primary and secondary lymphomas of the breast, though rare, should be considered in the differential diagnosis of breast malignancies. DOI: 10.21276/APALM.1335

Highlights

Extranodal Non-Hodgkin’s Lymphoma (NHL) of the breast is a rare entity
Mucosa associated lymphoid tissue (MALT) lymphoma is another common type of breast lymphomas.[2]
In patients diagnosed with NHL, primary involvement of the breast is seen in 0.4–0.7% of the cases.[3]

Summary

Introduction

Extranodal Non-Hodgkin’s Lymphoma (NHL) of the breast is a rare entity. It constitutes 0.04-1.1% of malignant tumours of the breast, 1.7-2.2% of extranodal lymphomas and 0.7% of all NHL.[1] primary NHL (PNHL) is the most frequent hematopoetic tumour of breast[1]. Biopsy was done from bilateral lesions and histopathological picture was similar showing sheets of dyscohesive tumour cells entirely replacing the normal breast tissue. Tumour cells were showing severe degree of pleomorphism. LCA, EMA and Ki-67 came out to be positive, and rest of the markers were negative. This directed us towards lymphoma.A final diagnosis of NHL was given.

Discussion

Findings

Conclusion