Abstract
Primary Non-Hodgkins lymphoma of the orbit is a rare presentation and the diffuse large B-cell lymphoma (DLCL) type of histology is much less commoner than the mucosa associated lymphoid tissue (MALT) and follicular lymphoma. A 70 years female patient presented with palpable mass arising from right orbit and proptosis of the right eye. CT scan suggested homogenous enhancing soft tissue mass affecting right lacrimal region without any bony destruction. Biopsy confirmed it to be a case of Primary non-Hodgkins lymphoma of diffuse large B-cell type with strongly positive CD 20. She was given 6 cycles of chemotherapy with R-CHOP after surgery. The patient is now asymptomatic one year after the last cycle of the chemotherapy.Bangladesh Journal of Medical Science Vol.15(4) 2016 p.624-627
Highlights
Lymphomas are malignant neoplasm of lymphoreticular system and mainly involve lymph nodes, spleen and other non-haemopoietic tissues
The tissue sample was sent for histopathological examination, which revealed Non-Hodgkin’s lymphoma of diffuse large B cell type and immuno-histochemistry confirmed the diagnosis with CD 20 strongly positive; CD 23, CD 3 & CD 5 negative
A palpable painless mass of an eye in elderly female must be diagnosed early in case of an orbital lymphoma before any bony destruction starts and that will improve the prognosis of the patient
Summary
Lymphomas are malignant neoplasm of lymphoreticular system and mainly involve lymph nodes, spleen and other non-haemopoietic tissues. Eighty percent of lymphomas are B-cell type, while 14% are T-cell type, with natural killer type (NK) forms only six percent 1. Primary orbital NonHodgkin’s Lymphoma is a rare presentation of extranodal non-Hodgkin’s lymphoma accounting for less than one percent of NHL 2. It affects primarily the lacrimal glands, conjunctiva, eyelids and orbits 3. Diffuse large B-cell lymphoma (DLCL) type of histology is much less commoner types of primary orbital NHL
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