Abstract
BackgroundPrimary mucinous carcinoma of the thyroid gland is a rare disease; only 6 cases of primary mucinous carcinoma of the thyroid have been previously reported. Primary mucinous carcinoma of the thyroid gland with incomplete tumor resection tends to be associated with a poor prognosis, resulting in death within a few months. An early and appropriate diagnosis may contribute to improvement in patient prognosis; however, it is extremely difficult to diagnose primary mucinous carcinoma of the thyroid. We present the seventh reported case of primary mucinous carcinoma in the thyroid gland; moreover, rhabdoid cells were detected, which, to our knowledge, is a novel finding.Case presentationAn 81-year-old Japanese woman was initially diagnosed with a poorly differentiated thyroid carcinoma, and she underwent a hemithyroidectomy. Pathological examination revealed the presence of abundant mucus and agglomeration of large atypical cells. Rhabdoid cells were also seen scattered among the tumor cells. Immunostaining was performed for various markers, and on the basis of these results, we diagnosed the lesion as primary mucinous carcinoma with rhabdoid cells in the thyroid gland. Ten months after surgery, recurrence was noted in the paratracheal lymph nodes; therefore, total resection of the residual thyroid gland and paratracheal lymphadenectomy with thyroid-stimulating hormone suppression were performed. The patient is currently alive and disease-free.ConclusionsThe current case is of interest not only because of the rare histological findings, but also because the patient achieved long-term survival following diagnosis of a mucinous carcinoma. We believe this report will be helpful for diagnosing future cases of mucinous carcinoma of the thyroid.
Highlights
Primary mucinous carcinoma of the thyroid gland is a rare disease; only 6 cases of primary mucinous carcinoma of the thyroid have been previously reported
The current case is of interest because of the rare histological findings, and because the patient achieved long-term survival following diagnosis of a mucinous carcinoma
Mucinous carcinomas are cancers characterized by an abundant extracellular production of mucus
Summary
Mucinous carcinomas are cancers characterized by an abundant extracellular production of mucus. Rhabdoid cells are large polygonal cells that contain an intracellular eosinophilic hyaline substance, and these cells are immunohistochemically positive for vimentin and keratin These cells have been reported to be detected in various types of malignant tumors. We encountered a rare case of primary mucinous carcinoma of the thyroid gland; the presence of rhabdoid cells, which are rarely found in thyroid carcinomas, was observed. This is the first report to describe the presence or rhabdoid cells in a primary mucinous carcinoma of the thyroid This case is extremely rare, and clinically, long-term survival in such cases is very rare, but this was achieved with complete tumor resection and TSH suppression therapy in this case. Abbreviations CEA, Carcinoembryonic antigen; CT, Computed tomography; PAS staining, Periodic acid–Schiff (PAS); TG, Thyroglobulin; TSH, Thyroid-stimulating hormone; TTF-1, Thyroid transcription factor-1
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