Primary melanoma of leptomeninge in a patient with giant congenital melanocytic nevus

Adriana Kamilly Leitão Pitman Machado,Débora Bacellar Cruz Nunes,Francisca Regina Oliveira Carneiro,Alena Margareth Darwich Mendes

doi:10.1016/j.abd.2019.11.002

Adriana Kamilly Leitão Pitman Machado, Débora Bacellar Cruz Nunes + Show 2 more

Open Access

https://doi.org/10.1016/j.abd.2019.11.002

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Abstract

Primary melanoma of leptomeninge in a patient with giant congenital melanocytic nevus

Highlights

Congenital Melanocytic Nevus (CMN) is characterized by pigmented lesions present at birth or in the first weeks of life
The risk of estimated lifetime MM-all sites for individuals with CMN is around 5%, with increased risk to 12% in patients with neurocutaneous melanosis
Mortality rate is close to 100% for Central Nervous System (CNS) MM cases and 70% of patients with neurocutaneous melanosis will die before 10 years of age.[1,3]

Summary

Introduction

Congenital Melanocytic Nevus (CMN) is characterized by pigmented lesions present at birth or in the first weeks of life. Dermatological examination revealed a brownish-black plaque, with evident hypertrichosis, extending from the cervical region to the knees, garment-like, with multiple satellite lesions on the face, upper and lower limbs (Fig. 1). The final diagnosis was primary melanoma of leptomeningeal. Primary CNS melanoma is a rare disease.

Results

Conclusion