Abstract
A review of 1,918 patients with cancer of the esophagus treated at Memorial Hospital from 1926 to 1968 disclosed 66 patients with malignant tumors other than typical epidermoid carcinoma. There were 45 patients with primary adenocarcinoma and 10 patients with variants of epidermoid carcinoma characterized histologically by prominent glandular or spindle cell features. Spindle cell metaplasia occasionally assumed a confusing pseudosarcomatous appearance suggesting leiomyosarcoma or fibrosarcoma when biopsy specimens were composed solely of spindle cell elements. Other unusual tumors of the esophagus included 2 malignant melanomas, 1 mucoepidermoid carcinoma, and I oat cell carcinoma. Primary lymphoma of the esophagus is exceedingly uncommon. Hodgkin's disease in I patient and reticulum cell sarcoma in 2 others later proved to be secondary to mediastinal involvement. The clinical and pathological features of these uncommon esophageal cancers are discussed.
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