Abstract
Malignant peripheral nerve sheath tumor is a rare soft tissue sarcoma. Breast is an extremely rare location of this lesion and presentation as a breast lump in the absence of pain or previous benign neural tumor is even rarer. We report such a lesion in a 60 year-old female who presented with hard and painless breast lump for 2 years. Histopathology revealed a malignant spindle cell tumor of low grade potential. It was subsequently confirmed to be malignant peripheral nerve sheath tumor (MPNST) on the basis of immunopositivity for vimentin, neurone specific enolase and S-100.
Highlights
Breast tumors are predominantly of epithelial origin, and non-epithelial tumors arising from indigenous structures in the breast are rare [1]
Breast is an extremely rare location of this lesion and presentation as a breast lump in the absence of pain or previous benign neural tumor is even rarer. We report such a lesion in a 60-year-old female who presented with hard and painless breast lump for 2 years
malignant peripheral nerve sheath tumor (MPNST) are known to arise within the field of irradiation, 9 to 36 yr after radiation therapy administered for treating previous malignancies [4]
Summary
Breast tumors are predominantly of epithelial origin, and non-epithelial tumors arising from indigenous structures in the breast are rare [1]. Primary pure breast sarcoma is a rare disease and constitutes 0.2% - 1.0% of all mammary malignancies [2]. The exact etiology is still unknown but these tumors frequently occur in patients suffering with neurofibromatosis Type I [NF 1]. MPNSTs are known to have an association with previous irradiation. MPNSTs are known to arise within the field of irradiation, 9 to 36 yr after radiation therapy administered for treating previous malignancies [4]. Immunohistochemical analysis proves to be helpful in indistinguishable cases. Though several cases of Malignant Peripheral Nerve Sheath Tumor (MPNST) of breast have been reported [5]. We report the first case with a one year follow up
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