Abstract
Neuroendocrine tumours (NETs) can arise in most organs of the body but are most frequently recorded in the gastrointestinal tract or lungs. They are rarely found in the head and neck region. The commonest site in the head and neck region is in the larynx. NETS in the larynx are almost invariably primary in origin. We describe a case of a middle-aged gentleman, a chronic smoker who was diagnosed with primary large cell neuroendocrine carcinoma of larynx with cervical nodal metastases. Large cell neuroendocrine carcinoma of larynx is a rare subset of NETs with a markedly more aggressive clinical course. He was initially treated with radiotherapy, and subsequently underwent total laryngectomy, total glossectomy. Right radical neck dissection and reconstruction with pectoralis major myocutaneous flap.
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