Abstract
Primary intraosseous squamous cell carcinoma (PISCC) is a rare malignant neoplasm with a predilection for the mandible caused by remnants of the odontogenic epithelium or odontogenic cysts and tumors. We report 2 cases of PISCC and discuss its clinicopathologic features. Two female patients received diagnosis in an oral medicine service. The first one, 40-years-old, showed manifestation in the posterior mandible, pathologic fracture, and pain. In the second one, 78-years-old, the lesion was in a mental region with no symptoms and a reddish skin appearance in the chin region. The patients’ imaging examinations showed radiolucent lesions and bone cortical expansion. Both microscopic examinations revealed neoplastic epithelial cells arranged in cords and sheets exhibiting pleomorphism and cellular atypia. The connective tissue stroma was permeated by a moderate mononuclear inflammatory infiltrate. Both patients were surgically treated and are under follow-up.
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