Abstract
Objective: Primary hypothyroidism is frequently manifested by weight gain. Moreover, treatment with L-Thyroxine reverses the weight gain in most subjects on achieving euthyroid state. However, the characteristic fat distribution contributing to these changes in body weight is not well documented. Therefore, the presence of central adiposity was examined in primary hypothyroidism prior to and after attaining and maintaining euthyroid state following L-Thyroxine therapy. Methods: Waist and hip measurements were conducted to determine waist: hip ratios in 55 men, ages 39 to 84 years at diagnosis of primary hypothyroidism established by subnormal Free T4 and supernormal TSH concentrations and again after their normalization by L-Thyroxine replacement therapy. The subjects were divided according to Body Mass Index (BMI-Kg/m2) into 3 groups; hypo T1, 20 men with BMI 30. 15 euthyroid normal (N) men matched for age and BMI in each group participated as controls. Results: Mean waist: hip ratio was significantly higher (p Conclusion: Central adiposity is a definitive clinical manifestation of primary hypothyroidism in men. Moreover, a significant improvement on achieving euthyroid state following L-Thyroxine therapy may deem central adiposity to be a major contributor to changes in body weight in primary hypothyroidism noted at diagnosis and on attaining and maintaining euthyroid state.
Highlights
Primary hypothyroidism frequently presents with non specific clinical manifestations and the diagnosis is established by subnormal serum Free T4 concentration and super normal TSH level
Waist and hip measurements were conducted to determine waist: hip ratios in 55 men, ages 39 to 84 years at diagnosis of primary hypothyroidism established by subnormal Free T4 and supernormal TSH concentrations and again after their normalization by L-Thyroxine replacement therapy
Weight gain is a prominent manifestation of primary hypothyroidism and attaining and maintaining euthyroid state with L-Thyroxine induces a decline in body weight in most subjects [1]
Summary
Primary hypothyroidism frequently presents with non specific clinical manifestations and the diagnosis is established by subnormal serum Free T4 concentration and super normal TSH level. Weight gain is a prominent manifestation of primary hypothyroidism and attaining and maintaining euthyroid state with L-Thyroxine induces a decline in body weight in most subjects [1]. L-Thyroxine treatment in patients with clinical and subclinical hypothyroidism is documented to. The contributions of various body constituents including total body fat and central fat distribution to these alterations in body weight in primary hypothyroidism prior to and following achieving euthyroid state has not been elucidated. We assessed the presence of central obesity in subjects with primary hypothyroidism prior to and after attaining and maintaining euthyroid state as documented by desirable normal free T4 and TSH concentrations with L-Thyroxine therapy
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