Abstract
Primary human hepatocytes (PHHs) isolated from livers retain proliferative properties when xeno-transplanted into chimeric mouse models1 or other species. Serial transplantation experiments in mice showed that PHH populations multiply by at least 100-fold per round,2 illustrating their greater than million-fold expansion potential. This has sparked widespread research into therapeutic hepatocyte transplantation for patients with liver conditions. Two major roadblocks that have limited clinical progress with hepatocyte transplantation are the lack of renewable high-quality human hepatocyte sources and the inability to efficiently correct inborn errors in PHHs.
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