Abstract
Primary human hepatocytes (PHHs) isolated from livers retain proliferative properties when xeno-transplanted into chimeric mouse models1 or other species. Serial transplantation experiments in mice showed that PHH populations multiply by at least 100-fold per round,2 illustrating their greater than million-fold expansion potential. This has sparked widespread research into therapeutic hepatocyte transplantation for patients with liver conditions. Two major roadblocks that have limited clinical progress with hepatocyte transplantation are the lack of renewable high-quality human hepatocyte sources and the inability to efficiently correct inborn errors in PHHs.
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
