Primary Gastric Lymphoma (Diffuse Large B Cell Type)

Anchal Manchanda,Milind Pandey,Raunak Kotecha,Sunita Vagha

doi:10.9734/jpri/2021/v33i37a31979

Abstract

The most frequent extra-nodal site of lymphoma is gastric lymphoma. The bulk of such lesions are extra nodal marginal zone B mucosal cell lymphoma correlated with lymphoid tissue (MALT) type or diffuse lymphoma of large B cells. We are reporting a case of diffuse major B-Cellular gastric lymphoma, which at first showed indigestion, abdominal heaviness, nausea and widespread weakness with 3-4 months of weight loss. In the antropyloric region and distal portion of lesser curvature of stomach suggestive of aetiology of cancer, the CT abdomen shows circumferential wall thickening. DLBCL has been confirmed by HPE and IHC. The neoplasm entered serosa and was found to have adherence to the pancreatic capsule in stage IIE of gastric lymphoma. Following the staging, treatment with an R-CHOP regimen (rituximab, cyclophosphamide, oncovin (vincristine), hydroxydaunorubicin, and prednisone) was done.

Highlights

Less than 5% of gastric cancers are due to primary gastric lymphoma [1-7]
CD20, BCL-2 and Ki-67 were positive and weak positivity for BCL-6 oncoprotein was seen. We concluded this case as a case of primary gastric lymphoma
The most frequent histological subtype of Non- Hodgkin’s lymphomas (NHL) is DLBCL. It consists of about twenty five percent of cases of nonHodgkins Lymphoma (NHL) in the developing world

Summary

INTRODUCTION

Less than 5% of gastric cancers are due to primary gastric lymphoma [1-7]. They are Non- Hodgkin’s lymphomas (NHL), but are known to be a different category from peripheral nodal NHL. The detection of primary stomach lymphoma needs histological examination with no presence of any peripheral lymphadenopathy or any organomegaly [8-16]. The involvement of stomach by a diffuse lymphoma formed in other place of the body suggests Secondary Gastric lymphoma. Gastric lymphoma is the paramount frequent extranodal site of lymphoma [15-21]. Most of these lesions are either extra nodal MALT or DLBCL. We document the case of diffuse large gastric B-cell lymphoma

CASE PRESENTATION

Findings

DISCUSSION

CONCLUSION