Abstract
IntroductionGastrointestinal tract (GIT) is the most common site of involvement of extranodal non-Hodgkin’s lymphoma (NHL). There is regional variation in anatomical distribution of extranodal NHL, stomach being the most common site followed by small intestine. Primary gastric lymphoma (PGL) predominantly involves the antrum and corpus of the stomach. It arises from mucosa-associated lymphoid tissue (MALT) and is of B-cell lineage and often associated with Helicobacter pylori infection. Primary gastric lymphoma often presents with nonspecific symptoms. The present study was undertaken to ascertain the clinicopathological characteristics of PGL at a tertiary care center in South India.Materials and methodsIt is a retrospective study from 2006 to 2016. Patient’s data were obtained from institutional medical records. The histopathology slides were reviewed. The relevant immunohistochemistry (IHC) markers done were leukocyte common antigen (LCA), CD3, CD20, CD79a, CD10, Bcl-2, Bcl-6, CD5, Cyclin D1, CD138, and Ki-67. Correlating with the immunoprofile, further subtyping was done.ResultsA total of 405 patients of NHL were seen during the study period, out of which 43 patients were PGL. There were 32 males and 11 females, with M:F of 2.9:1. The mean age at diagnosis was 58 years. Abdominal pain and new-onset dyspepsia were the commonly observed presenting symptoms. The common site of involvement was antrum (20). Diffuse large B-cell lymphoma (DLBCL) was the most common histological subtype. Helicobacter pylori infection was seen in 18 (41%) patients. Majority of the patients were in stages II and III.ConclusionIn our study, the initial presentation of PGL was with nonspecific symptoms like abdominal pain and new-onset dyspepsia. High degree of suspicion of such symptoms and biopsy of all suspicious lesions is essential for early detection. Diffuse large B-cell lymphoma was the most common histological subtype seen in our study.How to cite this article: Malipatel R, Patil M, Rout P, Correa M, Devarbhavi H. Primary Gastric Lymphoma: Clinicopathological Profile. Euroasian J Hepato-Gastroenterol 2018;8(1):6-10.
Highlights
Gastrointestinal tract (GIT) is the most common site of involvement of extranodal nonHodgkin’s lymphoma (NHL)
A total of 405 patients of NHL were seen during the study period, out of which 43 patients were Primary gastric lymphoma (PGL)
In our study, the initial presentation of PGL was with nonspecific symptoms like abdominal pain and new-onset dyspepsia
Summary
Gastrointestinal tract (GIT) is the most common site of involvement of extranodal nonHodgkin’s lymphoma (NHL). The primary GIT lymphomas are defined as those in which involvement of the alimentary tract predominates or those with symptoms of GIT involvement on presentation.[5,6] The diagnosis of PGL is often delayed due to nonspecific initial symptoms like vague abdominal pain and new-onset dyspepsia.[7] Primary gastric lymphoma predominantly involves the antrum and corpus of the stomach, arise from MALT, and are of B-cell lineage.[8,9] The different subtypes are DLBCL, extranodal marginal lymphomas of MALTs, Mantle cell lymphoma, follicular lymphoma, and very rarely T-cell lymphomas.[10,11,12] The present study was undertaken to ascertain the clinicopathological characteristics of PGL at a tertiary care center
Sign-in/Register to view highlights & summary Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a call
