Primary Gall Bladder Carcinoma: A one year prospective study at a tertiary care centre.

Abstract

Background: Gallbladder carcinoma is not an uncommon clinical entity in the Indian scenario, unlike western countries. It is predominantly a disease of females. Association between gallstones and Gallbladder carcinoma is strong. Its carcinogenesis follows a progression through a metaplasia−dysplasia−carcinoma sequence. An early diagnosis is essential as this malignancy progresses silently with a late diagnosis, often proving fatal. Therefore, every gallbladder should be subjected to routine histopathological examination because with identification of an earlygallbladder carcinoma a curative resection may be possible, and these patients have a good survival rate.Methods: This was a prospective study done on 22 cases of gallbladder carcinomas over a period of 1 year from 1st November 2017 to 1st November 2018.Results: Present study showed that gallbladder cancer is predominantly a disease of elderly females. In the present study, abdominal pain 18 cases (81.81%) followed by anorexia 15 cases (68.18%)and dyspepsia14cases(63.63%) was the most common presenting symptom present. Cholelithiasis was found in only 5 (22.72%) of our patients. Adenocarcinoma was the most common histopathologic variant found in 20 cases (90.90%) followed by squamous cell carcinoma 2cases (9.09%).Conclusions: Every gallbladder should be subjected to routine histopathological examination because with the early-stage disease a curative resection may be possible, and these patients have good long-term survival. JMS 2018: 21 (2):91-94