Abstract
Primary extranodal lymphomas in the head and neck region- a retrospective study from a tertiary cancer centre in south india
Highlights
Lymphomas are malignant neoplasms of immune system arising as a result of somatic mutations in lymphocyte progenitor cells
Head-Neck Extra Nodal Lymphoma (HNENL) are a distinct subset of lymphomas as they often remain localized to the primary site and shares
Previous studies mention that the symptoms of NHL are nonspecific (Epstein JB et al, 2001) the most common symptom being a non-pathognomoic swelling.75% of cases in our study presented as swelling in head and neck region, in concordance with the previous studies
Summary
Lymphomas are malignant neoplasms of immune system arising as a result of somatic mutations in lymphocyte progenitor cells. They constitute a clonally proliferated heterogenous group known for their spectrum of behaviour. Lymphomas range from relatively indolent to highly aggressive disease. They are broadly classified as Hodgkin’s lymphoma (HL) or NonHodgkin’s lymphoma (NHL).HL rarely presents in an extranodal site alone. About 25-30% of NHL are extranodal at presentation (Hanna E et al, 1997). The incidence of NHL is on a rise globally with upto 35% increase in incidence in some countries (Chan JK, 2000; Gospodarowicz MK, 1995). An improved survival rate is observed with an increase of 30-50.8% in 5 year survival rates (Shankland KR et al, 2012)
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