Abstract
Primary Extragonadal Yolk Sac Tumor Arising from the Urachus: A Case Report with Literature Review
Highlights
The urachus is a vestigial structure, the fibrous remnant of the allantois, a canal that drains the fetal urinary bladder and joins the umbilical cord
We report an extragonadal germ cell tumors (EGCT) in a 9-month-old male adding to the small number of documented reports of urachal yolk sac tumor (YST).[1]
Identification of Schiller-Duval bodies is pathognomonic for YST; these structures are present in only 20% of tissue specimens.[6]IHC plays a vital role in confirming the diagnosis of YST; a single, unique marker both sensitive and specific for this tumor is currently unavailable.[8]
Summary
The urachus is a vestigial structure, the fibrous remnant of the allantois, a canal that drains the fetal urinary bladder and joins the umbilical cord It typically regresses following the fifth gestational month to form the medial umbilical ligament.[1] Persistence of the urachus is well-documented as are the lesions associated with this structure: cysts, fistulae, sinuses, diverticula, and neoplasms.[1] rare, adenocarcinoma is the most common urachal malignancy; extragonadal germ cell tumors (EGCT) arising in this location are exceptionally rare.[1] we report an EGCT in a 9-month-old male adding to the small number of documented reports of urachal yolk sac tumor (YST).[1]. Multiple foci of metachromatic pink hyaline basement membrane-like material were present (Fig. 3A) Given these cytologic findings, the location of the mass, and an elevated AFP level, the possibility of yolk sac tumor (YST) was added to the differential diagnosis.
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