Abstract

Glioblastoma (GBM) is the most common malignant brain tumour in adults. On radiology, diagnostic dilemmas can arise with other brain pathologies like metastasis, brain abscess, and lymphoma. However, GBM mimicking a meningioma on radiology has been rarely reported. Here, we report a case of GBM with magnetic resonance imaging (MRI) features suggestive of meningioma. A 46-year-old female presented with a one-month history of headaches. The MRI brain suggested a broad-based extra-axial mass lesion in the left frontal convexity with cerebrospinal fluid (CSF) cleft sign with compression of underlying brain parenchyma. Overall, the MRI brain was suggestive of a cystic meningioma. The patient underwent gross total resection of the tumour under microscopy, and final histopathology confirmed GBM. Although GBM is usually an intra-axial tumour, it may present as an extra-axial mass lesion with radiological features mimicking meningioma. Therefore, it should be considered a differential diagnosis in patients with an extra-axial tumour displaying atypical malignant features.

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