Abstract
Squamous cell carcinoma (SCC) of the endometrium, whether primary or secondary to cervical cancer, is a rare entity. Primary endometrial squamous cell carcinoma in situ is even more uncommon; it usually occurs in postmenopausal women and has a strong association with pyometra. We report a 60-year-old multiparous postmenopausal woman who presented to the Hakeem Abdul Hameed Centenary Hospital, New Delhi, India, in May 2014 with a lower abdominal swelling corresponding in size to a pregnancy of 26 gestational weeks and vaginal discharge of one year's duration. A total abdominal hysterectomy with a bilateral salpingooophorectomy was performed, which revealed an enlarged uterus with pyometra. Histopathology showed that the entire endometrial lining had been replaced with malignant squamous cells without invasion of the myometrium. Immunohistochemistry revealed that the tumour cells were positive for p63 with a high Ki-67 labelling index. No adjuvant therapy was required and the patient was disease-free at a seven-month follow-up.
Highlights
Squamous cell carcinoma (SCC) of the endometrium, whether primary or secondary to cervical cancer, is a rare entity
We report a 60-year-old multiparous postmenopausal woman who presented to the Hakeem Abdul Hameed Centenary Hospital, New Delhi, India, in May 2014 with a lower abdominal swelling corresponding in size to a pregnancy of 26 gestational weeks and vaginal discharge of one year’s duration
It is essential to differentiate Primary endometrial squamous cell carcinomas (PESCCs) from endometrial SCC involvement based on the following strict pathological criteria recommended by Fluhmann: (1) no evidence of a coexisting endometrial adenocarcinoma or primary cervical SCC; (2) no connection between the endometrial tumour and squamous epithelium of the cervix; or Endometrial SCC usually occurs in postmenopausal women.[2]
Summary
Sujata Jetley,[1] Zeeba S. Abstract: Squamous cell carcinoma (SCC) of the endometrium, whether primary or secondary to cervical cancer, is a rare entity. Primary endometrial squamous cell carcinoma in situ is even more uncommon; it usually occurs in postmenopausal women and has a strong association with pyometra. العلاج الم ساعد مطلوبا و أ صبحت المري ضة خالية من الأمرا ض عند متتبعتها بعد سبعة أ شهر . خلايا ال سرطان الحر شفية؛ بطانة الرحم؛ تقيح الرحم؛ تقرير حالة؛ الهند:مفتاح الكلمات. Primary endometrial squamous cell carcinomas (PESCCs) are extremely rare the exact prevalence is not yet known. The majority of squamous cell carcinoma (SCC) cases represent an extension from the cervix, where SCC spreads superficially to the inner surface of the uterus and replaces the endometrium with carcinoma cells.[2] whether primary or secondary, endometrial SCC is rare and PESCC in situ even rarer
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