Abstract
An 84-year-old woman suffered from post-menopausal genital bleeding for 3 months. Based on the endometrial cytological findings (suggestive of high grade neuroendocrine carcinoma) showing that there were rosette-like and cord-like structures consisting of small rounded tumor cells with oval nuclei and scanty cytoplasm, radical hysterectomy was performed. Histopathological and immunohistochemical examinations on the operated specimens revealed primary high grade neuroendocrine carcinoma of the endometrium. Despite the extensive treatment against the malignancy, the patient died due to widespread metastases after 5 months after the surgery and autopsied.
Highlights
High grade neuroendocrine carcinoma (HGNEC) is a well-known aggressive epithelial malignancy that occurs predominantly in the lung
Rosette-like and cord-like structures of tumor cells were noted (Figure 2(b)). These findings showed characteristics of HGNEC developed in the endometrium
80 cases of endometrial HGNEC have been reported in the English-language literature [1]
Summary
High grade neuroendocrine carcinoma (HGNEC) is a well-known aggressive epithelial malignancy that occurs predominantly in the lung. Primary HGNEC of the endometrium is quite rare [1]-[3]. The presentation of endometrial HGNEC was related to symptomatic metastases [4], paraneoplastic syndromes such as retinopathy [5], or to Cushing syndrome due to ectopic ACTH production [6]. Histopathologic and cytologic features of HGNEC developed in a variety of tissues including lung were well-documented, only a few cases of primary endometrial HGNEC were documented. We report a case of primary HGNEC of the endometrium with cytological, histopathological and immunohistochemical features. Pathogenesis of this rare malignancy was discussed
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