Abstract
Primary dermal melanoma (PDM) is a rare distinct variant of cutaneous melanoma, predominantly occurring on the extremities of young or middle-aged adults. In comparison to conventional melanoma, PDM is characterized by unexpectedly prolonged survival and long-term survival. Thus, correct identification of this variant is crucial to avoid potential misdiagnosis and establish correct treatment and follow-up. In addition, no consensus and specific guidelines exist on the management of this peculiar subtype of cutaneous melanoma.
Highlights
Primary dermal melanoma (PDM) is a rare and distinct variant of cutaneous melanoma (CM), defined as a solitary dermal/subcutaneous nodule of melanoma and without an epidermal component
PDM is a rare variant of CM, affecting less than 1% of patients with melanoma
PDM is a rare variant of CM, affecting less than of patients with melanoma
Summary
Primary dermal melanoma (PDM) is a rare and distinct variant of cutaneous melanoma (CM), defined as a solitary dermal/subcutaneous nodule of melanoma and without an epidermal component. PDM histologically simulates cutaneous metastatic melanoma (CMM), from which it can often be indistinguishable. (Figure 1) The patient had no clinically palpable lymph node disease. There was no evidence of any underlying in situ component, ulceration, blood or lymphatic vessel invasion, regression, or associated nevus (Figure 2). Dermatopathology 2021, 8, component, ulceration, blood or lymphatic vessel invasion, regression, or associated component, bloodhost or lymphatic vessel invasion, regression,ofor nevus. Metastatic staging workup findings were negative, including and sentinel lymph node biopsy and full-body imaging studies with computed tomography positron ing studies with computed tomography and positron emission tomography.
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