Abstract
Skin lesions are not uncommon in Summary patients with Hodgkin's disease, but in such cases they are almost always part of a general involvement of organs and glands. Where the skin is involved by histologically characteristic Hodgkin's disease tissue, the prognosis is usually thought to be poor. Three patients are described here with skinbiopsy characteristic of the disease but who are still alive 16, 91/2, and 61/2 years from the time lesions were first noted. Two have never been treated. There was no evidence of involvement of other organs. There was some evidence of impaired cellular immune response in two of them, and the significance of this is discussed in relation to the immunological aspects of Hodgkin's disease. It is suggested that there is a rare variant of Hodgkin's disease in which lesions are confined to the skin, at least for a very lengthy period, and for which the prognosis is favourable.
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