Primary Cutaneous Follicle Centre Lymphoma with Hodgkin and Reed-Sternberg Like Cells: A Case Report and Review of the Literature.

Diana O. Treaba,Fatima A. Aldarweesh

doi:10.1155/2017/9549428

Abstract

An elderly woman with a complex medical history presented with a left forearm mass that slowly developed for several months. The excisional biopsy of this skin mass was remarkable for involvement by a follicle centre cell derived lymphoma with a nodular and diffuse pattern associated with a subset of scattered Hodgkin and Reed-Sternberg like cells. Fluorescence in situ hybridization studies did not detect the presence of IgH-bcl2 fusion transcript, and molecular studies were negative for immunoglobulin heavy chain gene rearrangements and EBV DNA sequences. Hodgkin and Reed-Sternberg like cells are rarely reported in FLs, and the association with primary cutaneous follicle centre lymphoma is extremely rarely seen. To our knowledge, our case is the second case of primary cutaneous follicle centre lymphoma with Hodgkin and Reed-Sternberg like cells.

Highlights

Follicular lymphoma comprises approximately 20% of all lymphomas in the United States and has a slight female predominance [1, 2]
Primary cutaneous follicle centre lymphoma (PCFCL) is a separate diagnostic entity in the WHO 2008 classification [6] and in the 2016 WHO criteria revision [7] accounting for approximately 60% of the primary cutaneous B-cell lymphomas [6]
Dissemination to extracutaneous sites occurs in approx. 10% of these patients. Both classical Hodgkin lymphoma and nonHodgkin lymphomas have been reported in the same person and occasionally follicular lymphoma (FL) have H/RS-like large cells, within the neoplastic nodules or at their periphery [14,15,16,17,18,19,20,21]

Summary

Introduction

Follicular lymphoma comprises approximately 20% of all lymphomas in the United States and has a slight female predominance [1, 2]. Primary cutaneous follicle centre lymphoma (PCFCL) is a separate diagnostic entity in the WHO 2008 classification [6] and in the 2016 WHO criteria revision [7] accounting for approximately 60% of the primary cutaneous B-cell lymphomas [6]. This lymphoma may occur as a solitary plaque or mass, especially involving the head or trunk area, may form a small group of closely located lesions, and rarely may be multifocal. Lymphoma with H/RS cells, a very rare diagnostic entity reported only in one prior case in the English medical literature

Report of a Case

Discussion

Findings

Conclusion