Primary cutaneous CD30+ lymphoproliferative disorders with DUSP22 translocation.

Abstract

Primary cutaneous CD30+ lymphoproliferative disorders (LPD) encompass abroad category of clonal Tcell proliferations with varied clinical presentations. Classically, lymphomatoid papulosis (LyP) and primary cutaneous anaplastic large cell lymphoma (ALCL) have been recognized as distinct clinicopathological entities according to their differing clinical features. Recently, asubset of LyP and both cutaneous and systemic ALCL have been shown to carry aDUSP22 translocation [1-3], adefining molecular feature for the novel entity "LyP with DUSP22t" [1]. In cutaneous biopsies, both primary cutaneous DUSP22-translocated ALCL and LyP with DUSP22 rearrangements are characterized by abiphasic pattern with significant small cell epidermotropism. Adistinct protein expression profile with preserved T Cell Receptor (TCR) expression, positivity for CD30, LEF1, HLA, and CD58, and negativity for cytotoxic marker expression as well as phospho-STAT3 protein is consistently found in these cases.