Primary Cutaneous CD30+ Anaplastic Large Cell Lymphoma: A Rare Association With Large Plaque Parapsoriasis.

Ionela Manole,Marius-Cristian Valcoci,Alexandra-Irina Butacu,Iulia-Elena Negulet,George-Sorin Tiplica

doi:10.7759/cureus.11228

Abstract

Primary cutaneous CD30-positive lymphoproliferative disorders represent the second most common subgroup of cutaneous T-cell lymphomas and include lymphomatoid papulosis, primary cutaneous anaplastic large cell lymphoma, and borderline lesions. Primary cutaneous anaplastic large cell lymphoma is characterized by the presence of solitary or localized nodules or tumors located on the extremities or the cephalic or cervical region. Large plaque parapsoriasis is a chronic inflammatory disorder that associates a high risk of progression to mycosis fungoides. We report a case of CD30+ primary cutaneous anaplastic large cell lymphoma in a patient with a long history of large plaque parapsoriasis.

Highlights

Peripheral T-cell lymphomas encompass 15% of non-Hodgkin lymphomas in adults [1]
Primary cutaneous anaplastic large cell lymphoma is characterized by the presence of solitary or localized nodules or tumors located on the extremities or the cephalic or cervical region
We report a case of CD30+ primary cutaneous anaplastic large cell lymphoma in a patient with a long history of large plaque parapsoriasis

Summary

Introduction

Primary cutaneous CD30-positive lymphoproliferative disorders represent the second most common subgroup of cutaneous Tcell lymphomas after mycosis fungoides and include lymphomatoid papulosis and primary cutaneous anaplastic large cell lymphoma [2]. These three clinical entities present similar histopathological findings and are differentiated based on clinical findings and evolution of lesions. Even though large plaque parapsoriasis can progress into mycosis fungoides, its association with C30positive anaplastic large cell lymphoma has rarely been described in the medical literature. We present a case of a C30-positive anaplastic large cell lymphoma in a patient with a long history of large plaque parapsoriasis, arising after a local trauma. Follow-up after seven fractions of radiation therapy revealed a favorable outcome, with a significant decrease in the diameter of the ulcerated lesion (Figure 3)

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Disclosures