Abstract
An eleven-year-old spayed American Akita bitch rapidly developed a mammary tumour which was surgically removed. The histological examination revealed the tumour to be a sarcoma that presented positive immunohistochemical staining against vimentin and protein S 100. There was no staining against pan-actin. Based on the histological aspect and the pattern of immunohistochemical staining the diagnosis of primary extraskeletal chondrosarcoma of the mammary gland was considered most probable. Two months later the patient was euthanized with recurrent local tumour and metastases in the lungs.
Highlights
Chondrosarcomas are malignant tumours characterized by the development of neoplastic chondrocytes in a fibrilary matrix
Based on the histological aspect and the pattern of immunohistochemical staining the diagnosis of primary extraskeletal chondrosarcoma of the mammary gland was considered most probable
Chondrosarcomas originate from pluripotential mesenchymal cells that can differentiate into chondrocytes [1]
Summary
Chondrosarcomas are malignant tumours characterized by the development of neoplastic chondrocytes in a fibrilary matrix. Chondrosarcomas originate from pluripotential mesenchymal cells that can differentiate into chondrocytes [1]. The overwhelming majority of chondrosarcomas occurs in bones. They are called appendicular if located in the limbs, but they occur in flat bones such as ribs and scapulae. The occurrence of a chondrosarcoma outside of the bones (extraskeletal) is extremely rare [2,3]. Some cases of extraskeletal primary chondrosarcomas in dogs have been described in different locations, of which the mammary gland is the most common [4]. Chondrosarcoma of the mammary gland is exceptional in clinical practice, and we could not find any published case in an Akita, either Japanese or American
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