Abstract
Endodermal sinus tumors are rare malignant germ cell tumors that usually originate from the gonads and are rarely observed extragonadally. Pure primary endodermal sinus tumors of the cerebellar hemisphere are extremely rare and patients diagnosed with the disease often have a poor prognosis. The symptoms of YSTs are unspecific and associated with the location of tumors. Intracranial YSTs (such as cerebellar hemispheres) always present with symptoms including headache and poor vision. The present study reports the case of a three-year-old male who presented to The First Affiliated Hospital of Nanchang University (Nanchang, China) with a headache that had persisted for one month, and then worsened for the last 10 days. This was accompanied by vomiting and gait disturbance. An abnormal signal mass was identified in the left cerebellar hemisphere on brain magnetic resonance imaging. The case initially presented as a medulloblastoma and the patient was followed up for six months. The final pathology report revealed an endodermal sinus tumor, also known as a yolk sac tumor. Six months following resection of the left cerebellar tumor, the patient succumbed to recurrence of the disease, due to acute vomiting and severe headache.
Highlights
At present, no studies have analyzed the total incidence of yolk sac tumors (YSTs), it has been reported that YSTs most commonly occur in the pediatric testis [1]
The current study presents the case of a three‐year‐old male with a cerebellar YST, which initially presented as a medulloblastoma
Endodermal sinus tumors are rare malignant germ cell tumors (GCTs) that usually originate from the gonads and are rarely observed extragonadally [4]
Summary
No studies have analyzed the total incidence of yolk sac tumors (YSTs), it has been reported that YSTs most commonly occur in the pediatric testis [1]. A three‐year‐old male presented to The First Affiliated Hospital of Nanchang University (Nanchang, China) with a headache that had persisted for one month, and worsened for the last 10 days. The imaging revealed an abnormal signal mass in the left cerebellar hemisphere (Fig. 1), but no tumorous lesions were identified at other sites. The diagnosis of an endodermal sinus tumor originating in the left cerebellar hemisphere was determined. Subsequent to one month, MRI of the brain revealed tumor recurrence in the same region (Fig. 4). After another month, the relapsing mass had increased in size (Fig. 5) and the patient's conditioned had worsened, resulting in the patient succumbing to the disease six months after the diagnosis
Sign-in/Register to view highlights & summary Sign-in/Register to access full text options 
Free) 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a call
