Abstract
Synovial sarcoma comprises approximately 10% of all soft tissue sarcoma diagnoses; a primary synovial sarcoma of the myocardium is exceedingly rare. There have been very few cases reported in the literature thus far. With the identification of the characteristic and diagnostic chromosomal abnormality t(X;18), this may become an increasingly recognized entity. Our report adds to the limited published cases of primary cardiac synovial sarcoma with the characteristic t(X;18). Further elucidation of the effects of this translocation on the cell cycle may lead to directed therapies in the future.
Highlights
Synovial sarcoma is an uncommon malignancy, comprising approximately 10% of all soft-tissue sarcomas (STS) [1]
A characteristic chromosomal abnormality for synovial sarcoma has been identified for all morphologic subtypes: t(X;18) [4]
The heart was inspected and tumor was seen through the epicardial surface between the right atrium and aorta
Summary
Synovial sarcoma is an uncommon malignancy, comprising approximately 10% of all soft-tissue sarcomas (STS) [1]. Unlike other STS, the synovial type occurs most often in children and young adults and is an aggressive tumor with 10-year-old survival rates reported in some series as low as 0–20% [2, 3]. It is divided into three subtypes: biphasic, monophasic and poorly differentiated. Primary cardiac synovial sarcoma with the characteristic t(X;18) has rarely been reported in the medical literature (see Table 1) [5,6,7,8,9,10]. We report a recent case from Shands Hospital at the University of Florida
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