Primary Carcinoma of Urinary Bladder

Abstract

We report the experience of 303 bladder concers initially treated at the department of Urology, National Taiwan University Hospital in 1977-1989. The male to female ratio was 3.4:1. Among 303 bladder cancers, 268(88.4%) cases were transitional cell carcinoma (TCC); 20(6.6%) cases squamous cell carcinoma. Painless gross hematuria (91%of cases) was the most frequently presenting symptom. There was no relationship be tween duration of hematruria and stage of bladder cancer. Younger patients (＜35 y/o) had lower stage of bladder TCC with better prognosis. The 5-year observed survival rate of TCC was 66.4%; SCC 19.5%; and adenocarcinoma 18.5% respectively. For TCC, the 5-year survuival rate of stage a disease was 85.5%;stage B 57.6%; stage C 23.8%; and stage D 0%. The 5-year survival rate of TCC grade-I was 97.8%;grade-Ⅱ 78.6%; grade-Ⅲ/Ⅳ 44.6%. The 5-year disease free rate of TCC stage A grade-∣ was 90.3%; grade-Ⅱ 51.8%; grade-Ⅲ/Ⅳ 43.8%. The 5-year disease ofree rate of superficial bladder TCC patients with prophylatic intravesical chemotherapy was 64.5%; while patients without prophylaxis was 39.9% (P＜0.05). Abnormally high stage of bladder cancer was noted in the patients who came from Chia-Yi and Tai-Nan district where a perpheral vascular disease called “black foot disease” is endemic now.