Abstract
In 9 years in Kenya, 34 examples of primary liver cancer wer diagnosed in patients in the first two decades of life. This represents 4.7% of all liver cancers during this period. The larger proportion (29) were hepatocellular carcinoma. In the second decade, there was a notable association with macronodular cirrhosis. Analogy with experimental work suggests that cells in mitotic cycle may be more vulnerable to the effect of environmental carcinogens. Five examples of hepatoblastoma were identified at ages from 2 months to 14 years; none showed the features of "mixed" tumours. The ratio of hepatoblastoma to hepatocellular carcinoma was the reverse of that found in other large series of juvenile hepatic tumours. The histopathological features of these tumours are described and problems of their classification are discussed.
Highlights
Summary.-In 9 years in Kenya, 34 examples of primary liver cancer were diagnosed in patients in the first two decades of life
The ratio of hepatoblastoma to hepatocellular carcinoma was the reverse of that found in other large series of juvenile hepatic tumours
IT has been said that there is a "strange cancer apparently does not reach the very absence" of primary cancer of the liver high incidence found in Mozambique in children in parts of the world in which (Torres, Purchase and van der Watt, it is common in adults (Edmondson, 1956; 1970), it comes fifth in the table of Fraumeni, Miller and Hill, 1968)
Summary
Summary.-In 9 years in Kenya, 34 examples of primary liver cancer were diagnosed in patients in the first two decades of life. This represents 4.7O% of all liver cancers during this period. How- decades of life (Bowry and Cameron, ever, the statement is not altogether 1976) This revealed a considerable numsupported by the small number of papers ber of cases of primary cancer of the liver. "lack of observation or reporting", and million (1969 census) The histopathological this appears to be confirmed by Anthony's later finding in Uganda (1973) of 11 examples of liver cell carcinoma in the under-twenties.
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