Abstract
Mucinous cystadenocarcinoma of the breast is a rare primary breast carcinoma having distinct clinical behavior and a favorable prognosis. It has a characteristic morphology that must be differentiated from metastatic ovarian and pancreatic mucinous adenocarcinoma. The etio-pathogenesis, genetic profile, and treatment of this tumor are controversial. Here, we report a case of primary mucinous cystadenocarcinoma of the breast in a 61-year-old female. The case is of interest since it is uncommon and has peculiar clinical and morphological features.
Highlights
Mucin-producing carcinomas are unusual primary malignancies of the breast and constitute about 1%-4% of total breast cancer
According to the WHO classification, the mucin-producing carcinomas of the breast are divided into four histologic subtypes, including mucinous carcinoma, mucinous cystadenocarcinoma (MCA), columnar cell mucinous carcinoma (CCMC), and signet ring cell carcinoma [1]
The tumor exhibited features like the association with ductal carcinoma in situ (DCIS), lymph node metastasis, and estrogen receptor positivity which are rarely reported in the literature
Summary
Mucin-producing carcinomas are unusual primary malignancies of the breast and constitute about 1%-4% of total breast cancer. We report an unusual case of primary MCA of the breast in a 61-year-old lady presenting as a cystic mass. The tumor exhibited features like the association with ductal carcinoma in situ (DCIS), lymph node metastasis, and estrogen receptor positivity which are rarely reported in the literature. The left breast showed a well-defined oval-shaped high-density mass with a cystic component in the retro areolar region associated with architectural distortion. Overall findings were assessed as Breast Imaging Reporting and Data System (BIRADS) category 5 (highly suggestive of malignancy). She underwent a core needle biopsy for both right and left-sided lesions. The adjacent breast showed foci of conventional, intermediate nuclear grade, DCIS. Eight months post-surgery, the patient is doing well and has been advised regular follow-up visits
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