Abstract
Layer-by-layer (LbL) self-assembly is the technology used in intermolecular static electricity, hydrogen bonds, covalent bonds and other polymer interactions during film assembling. This technology has been widely studied in the drug carrier field. Given their use in drug delivery systems, the biocompatibility of these potential compounds should be addressed. In this work, the primary biocompatibility of poly(lactide-co-glycolide)-(poly-L-orithine/fucoidan) [PLGA-(PLO/fucoidan)] core–shell nanoparticles (NPs) was investigated. Atomic force microscopy revealed the PLGA-(PLO/Fucoidan)4 NPs to be spherical, with a uniform size distribution and a smooth surface, and the NPs were stable in physiological saline. The residual amount of methylene chloride was further determined by headspace gas chromatography, in which the organic solvent can be volatilized during preparation. Furthermore, cell viability, acridine orange/ethidium bromide staining, haemolysis and mouse systemic toxicity were all assessed to show that PLGA-(PLO/fucoidan)4 NPs were biocompatible with cells and mice. Therefore, these NPs are expected to have potential applications in future drug delivery systems.
Highlights
Nanocarriers, which have specific properties such as nanosize and controlled drug delivery behaviour, have been widely studied in drug delivery systems
The atomic force microscopy (AFM) results revealed that the LbL NPs are spherical, with a uniform distribution of particle size and adhesion between the particles
Patients with advanced cancer who received fucoidans via oral administration exhibited a significant reduction in major pro-inflammatory cytokines after two weeks [24]
Summary
Nanocarriers, which have specific properties such as nanosize and controlled drug delivery behaviour, have been widely studied in drug delivery systems. Of nanocarriers, layer-by-layer (LbL) self-assembled carriers have a better controlled release effect mainly 2 due to the LbL structure. The LbL self-assembly technique can combine different polyelectrolyte materials and nanoparticles (NPs) to construct a carrier with an ultra-thin film multilayer structure. The controlled release effect of LbL self-assembled drug carriers is primarily manifested through the following: (1) the environmentdependent multilayer assembly characteristics determine the controlled release of the drug by regulating the lamellar membrane structure; (2) the assembly characteristics of a variety of polymers include the inclusion of hydrolysis, enzymolysis, stimulus response, etc. The controlled release effect of LbL self-assembled drug carriers is primarily manifested through the following: (1) the environmentdependent multilayer assembly characteristics determine the controlled release of the drug by regulating the lamellar membrane structure; (2) the assembly characteristics of a variety of polymers include the inclusion of hydrolysis, enzymolysis, stimulus response, etc. to regulate drug release; and (3) the preparation method of LbL self-assembly technology by designing the spatial distribution of drugs allows multilayer films to achieve controllable drug release [4,5]
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