Abstract
Primary bilateral macronodular adrenal hyperplasia (BMAH) is a rare cause of Cushing's syndrome, and is more often diagnosed as bilateral adrenal incidentalomas with modest cortisol production. Combined germline and somatic mutations of armadillo repeat containing 5 gene (ARMC5) were identified in familial cases, in ~25% of apparently sporadic cases, and in the relatives of index cases; genetic testing can now allow early diagnosis. The recent findings of ectopic adrenocortical production of ACTH in clusters of BMAH tissues and its regulation by aberrant G-protein-coupled receptors open new horizons for eventual medical therapy using melanocortin 2 receptor and GPCR antagonists.
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
