Primary angiosarcoma of breast: A case report and literature review

Abstract

Introduction and importancePrimary angiosarcoma of breast (PAB)33Abbreviation: PAB, primary angiosarcoma of breast. is a rare and aggressive malignancy with limited published literature. This article aims to disclose the diagnosis and treatment of this case, review previous case reports, and provide clinical experience to breast surgeons. Case presentationA 36-year-old Asian female presented with a diffuse mass growing rapidly in her left breast. The ultrasonography (USG)44Abbreviation: USG, ultrasonography. suspected granulomatous mastitis. The core needle biopsy (CNB)55Abbreviation: CNB, core needle biopsy. confirmed the diagnosis of breast angiosarcoma (AS).66Abbreviation: AS, angiosarcoma. She underwent mastectomy without axillary lymph node dissection (ALND)77Abbreviation: ALND, axillary lymph node dissection. followed by adjuvant chemotherapy. About 11 months after mastectomy, the patient had bone metastasis. Clinical discussionPAB is a rare vascular neoplasia, characterized by aggressive patterns, poor prognosis, and high malignant potential. It is difficult to diagnose or differentiate only by clinical or imaging examination. Biopsy and immunohistochemical staining are the most reliable method. Mastectomy is the most common treatment. ConclusionPAB is a rare and malignant cancer. We should pay attention to the diffuse progressive masses in the breast of young female, and perform MRI and biopsy if necessary. Mastectomy is the only treatment known that has proven to benefit these patients. There are no evidence-based guidelines regarding treatment.