Abstract
Amyloidosis consists of extracellular deposition of amyloid (starch like), a protein with a fibrillary structure, in one or more body sites. It was first described by Virchow in 1853.1 In the urinary tract, amyloid deposition usually starts from kidney to renal pelvis, ureters, urinary bladder, urethra and even penis. The kidney is nearly always involved in secondary amyloidosis and in approximately 50% of the cases of primary amyloidosis. Amyloidosis of the urinary bladder is uncommon, but amongst the various sites in the lower urinary tract, it is the most commonly involved organ.2, 3 Both sexes are equally affected between the fifth and seventh decade. Painless gross haematuria is the main presenting symptoms in most (>75%) cases.2 Both primary and secondary amyloidosis may involve the bladder, isolated primary vesical amyloidosis being more common than secondary involvement4 and the lesions can be easily confused with malignancy because of its appearance on imaging as well as on cystoscopy.3, 4 Hence, a high index of suspicion is always warranted whenever one encounters such pathology.
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