Primary amines as new carbonyl surrogate in Kabachnik‐fields reaction: A new metal free one pot approach to synthesize α‐Aminophosphonates in water

Abstract

A new, simple and greener approach for the synthesis of α-aminophosphonates via oxidative deamination followed by kabachnik-Fields reaction has been developed. The methodology involves in situ generation of aldehydes from benzyl amines which then reacts with aryl amine and trialkyl phosphite in one-pot manner and gives the α-aminophosphonate products in excellent yields. The synthesis offers an alternative strategy which involves benzyl amines as carbonyl surrogate. The developed method has a wide substrates scope and offers the opportunity of synthesizing α-aminophosphonates in good yield. Further, the synthesis uses aqueous hydrogen peroxide (H2O2) as a green oxidant and enables to synthesize these products under mild and metal-free conditions in water as a medium.