Primary Amine Discrimination Using a 19F NMR Reporter Bearing two Different Fluorine‐Containing Moieties

Abstract

AbstractA new concept for analyzing primary amines using a novel 19F NMR reporter bearing two different fluorine‐containing moieties is described herein. The 19F NMR reporter, 4‐fluoro‐2‐(trifluoroacetyl)‐aminobenzaldehyde, was readily synthesized from a commercially available fluorine‐containing anthranilic acid derivative in two steps. After the imine formation of the NMR reporter with amines, 2D plots of two 19F shift‐related values were obtained. Amines with various types and sizes could be discriminated on the plot.