Abstract
Alveolar soft-part sarcoma (ASPS) is an uncommon, aggressive soft-tissue neoplasm, occurring in less than 1% of sarcomas. It is typically found in the head and neck tissues in children or in the deep soft tissues of the lower extremities in young adults. This tumor arises primarily within the skeletal muscles or musculofascial planes. Primary involvement of bone is extremely rare. ASPS has poor prognosis with a propensity for recurrence as well as distant metastasis. In this report, we present a 25-year-old male with primary ASPS in the left scapular bone and discuss the histopathological and immunohistochemical features of this sarcoma.
Highlights
Alveolar soft part sarcoma (ASPS) is rare, distinctive soft tissue sarcoma composed of large, uniform, epithelioid cells and characterized by ASPSCR1-TFE3 fusion gene [1]
We present a 25-year-old male with primary Alveolar soft-part sarcoma (ASPS) in the left scapular bone and discuss the histopathological and immunohistochemical features of this sarcoma
The pathological diagnosis of ASPS is based on morphological features, including large, uniform, epithelioid cells with eosinophilic abundant granular cytoplasm arranged in sol10 id nests and/or alveolar structures [14]
Summary
Alveolar soft part sarcoma (ASPS) is rare, distinctive soft tissue sarcoma composed of large, uniform, epithelioid cells and characterized by ASPSCR1-TFE3 fusion gene [1]. It accounts for less than 1% of all soft tissue malignancies, and generally occurs between 15 and 35 years of age with a notable female predominance [1] [2]. 2 cases with primary involvement of the scapular bone have been reported previously in the literature [3] This case highlights some of the histopathological pitfalls in the diagnosis of ASPS and the possible unusual site of presentation
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