Primary aldosteronism: clinical staff conference at the National Institutes of Health.

Abstract

Clinical Staff Conference1 March 1958PRIMARY ALDOSTERONISM: CLINICAL STAFF CONFERENCE AT THE NATIONAL INSTITUTES OF HEALTHFREDERIC C. BARTTER, M.D., EDWARD G. BIGLIERI, M.D.FREDERIC C. BARTTER, M.D.Search for more papers by this author, EDWARD G. BIGLIERI, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-48-3-647 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptDr. Frederic C. Bartter: The diagnosis of primary aldosteronism is suggested by the findings of hypertension, hypokalemia and alkalosis.The chemical abnormalities result from the continuous autonomous overproduction of aldosterone, resulting in excessive excretion of hydrogen and potassium ions, presumably exchanged for sodium ions by renal tubular cells. As potassium depletion ensues, (1) urinary ammonia excretion increases, and the urine may become alkaline despite continued excessive hydrogen excretion, (2) the ability to produce a concentrated urine, even with exogenous pitressin, may be lost, with resultant relative water loss and hypernatremia, (3) further renal damage may result in nitrogen retention and...Bibliography1. Bartter FC: The role of aldosterone in normal homeostasis and in certain disease states, Metabolism 5: 369, 1956. MedlineGoogle Scholar2. Conn JW: Primary aldosteronism—a new clinical syndrome, J. Lab. and Clin. Med. 45: 1, 1955. Google Scholar3. HoltenPosborg Petersen CV: Malignant hypertension with increased secretion of aldosterone and depletion of potassium, Lancet 2: 918, 1956. CrossrefGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Bethesda, Maryland*Received for publication November 18, 1957.This is an edited transcription of a combined clinical staff conference at the Clinical Center, Bethesda, Maryland, by the National Heart Institute, National Institutes of Health, Public Health Service, Department of Health, Education, and Welfare.Requests for reprints should be addressed to Charles G. Zubrod, M.D., National Institutes of Health, Bethesda 14, Maryland. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byFamilial HyperaldosteronismGenetics of Familial HyperaldosteronismAn Update on Familial HyperaldosteronismFamilial Hyperaldosteronism Type IIIHypertension with or without adrenal hyperplasia due to different inherited mutations in the potassium channel KCNJ5Das Bartter SyndromLow-renin (“primary”) hyperaldosteronismAldosterone: Review of its physiology and diagnostic aspects of primary aldosteronismComparison of steroidogenesis in adrenal tissue and adrenal adenoma from a case of primary aldosteronismEndokrinologie in der KinderheilkundeREFERENCESOn the pathogenesis of metabolic alkalosis in hyperaldosteronismLiteraturverzeichnisMETABOLIC AND HORMONAL STUDIES IN A PATIENT WITH PRIMARY ALDOSTERONISM, PRESENTING WITH ACUTE HYPOKALAEMIC PARESIS INDUCED BY CHLOROTHIAZIDEAldosterone in ChildhoodPrimary Aldosteronism with Suppressed Plasma Renin Activity Due to Bilateral Nodular Adrenocortical HyperplasiaFRED H. KATZ, M.D.Childhood primary aldosteronism with bilateral adrenocortical hyperplasia: Plasma renin activity as an aid to diagnosisDisorders of Adrenal Steroid BiogenesisDisorders of Aldosterone Secretion in ChildhoodConn's syndrome due to adrenal hyperplasia with hypertrophy of zona glomerulosa, relieved by unilateral adrenalectomyPhysiology of the kidneyDisorders of renal functionDie kindlichen Nebennieren und ihre PathologieAldosteron und AldosteronismusClinical characteristics of primary aldosteronism from an analysis of 145 casesAldosterone: Its Biochemistry and Physiology�ber das Syndrom des prim�ren Hyperaldosteronismus bei NierenarteriendrosselungThe Salivary Sodium-Potassium RatioPrimary AldosteronismDer primäre AldosteronismusPRIMARY ALDOSTERONISM WITH SEVERE HYPERTENSION RELIEVED BY ADRENALECTOMYPRIMARY ALDOSTERONISM (CONN'S SYNDROME): REPORT OF A CASE, AND AN ANALYSIS OF PUBLISHED CASESAldosteronism and Arterial HypertensionALDOSTERONE-SECRETING ADENOMA: REPORT OF A CASE IN A JUVENILE*†MILTON G. CRANE, M.D., JOHN E. HOLLOWAY, M.D., WILLIAM G. WINSOR, M.D.ELECTROLYTE METABOLISM AND ALDOSTERONE SECRETION IN BENIGN AND MALIGNANT HYPERTENSION*†JOHN H. LARAGH, STANLEY ULICK, VLODZIMIERZ JANUSZEWICZ, WILLIAM G. KELLY, SEYMOUR LIEBERMANPRIMARY ALDOSTERONISM-CONN'S SYNDROMESyndrome of Mineralocorticoid Excess Due to Bilateral Adrenocortical HyperplasiaAldosteroneTHE SYNDROME OF MINERALOCORTICOID EXCESS 1 March 1958Volume 48, Issue 3Page: 647-654KeywordsExcretionHypernatremiaHypertensionNephritisPotassiumPrevention, policy, and public healthSodiumTubular cellsUrineVasopressin ePublished: 1 December 2008 Issue Published: 1 March 1958 PDF downloadLoading ...